27 April 2016 Two teams, one goal
16 April 2016 Two new compounds found to treat Ewing sarcoma
Herzog J et al. Trabectedin followed by irinotecan can stabilize disease in advanced translocation-positive sarcomas. Sarcoma.
Harlow ML et al. Lurbinectedin inactivates the Ewing sarcoma oncoprotein EWS-FLI1 by redistributing it within the nucleus. Cancer Res.
Osgood CL et al. Identification of mithramycin analogs with improved targeting of the EWS-FLI1 transcription factor. Clin Cancer Res.
Caropreso V et al. In press. Englerin A inhibits EWS-FLI1 DNA binding in Ewing sarcoma cells.
J Biol Chem.
We are always looking to recruit lab members at all levels. Please contact Dr. Grohar with questions.
Children’s Oncology Group (Steering Committee member and vice chair of the Ewing Sarcoma Biology Committee)
SARC (member of the Developmental Therapeutics Committee)