27 April 2016 Two teams, one goal
16 April 2016 Two new compounds found to treat Ewing sarcoma
Herzog J et al. Trabectedin followed by irinotecan can stabilize disease in advanced translocation-positive sarcomas. Sarcoma.
Harlow ML et al. Lurbinectedin inactivates the Ewing sarcoma oncoprotein EWS-FLI1 by redistributing it within the nucleus. Cancer Res.
Osgood CL et al. Identification of mithramycin analogs with improved targeting of the EWS-FLI1 transcription factor. Clin Cancer Res.
Caropreso V et al. In press. Englerin A inhibits EWS-FLI1 DNA binding in Ewing sarcoma cells.
J Biol Chem.
We are always looking to recruit lab members at all levels. Please contact Dr. Grohar with questions.